Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms

Hypertension and type 2 diabetes are common comorbidities. Hypertension is twice as frequent in patients with diabetes compared with those who do not have diabetes. Moreover, patients with hypertension often exhibit insulin resistance and are at greater risk of diabetes developing than are normotensive individuals. The major cause of morbidity and mortality in diabetes is cardiovascular disease, which is exacerbated by hypertension. Accordingly, diabetes and hypertension are closely interlinked because of similar risk factors, such as endothelial dysfunction, vascular inflammation, arterial remodelling, atherosclerosis, dyslipidemia, and obesity. There is also substantial overlap in the cardiovascular complications of diabetes and hypertension related primarily to microvascular and macrovascular disease. Common mechanisms, such as upregulation of the renin-angiotensin-aldosterone system, oxidative stress, inflammation, and activation of the immune system likely contribute to the close relationship between diabetes and hypertension. In this article we discuss diabetes and hypertension as comorbidities and discuss the pathophysiological features of vascular complications associated with these conditions. We also highlight some vascular mechanisms that predispose to both conditions, focusing on advanced glycation end products, oxidative stress, inflammation, the immune system, and microRNAs. Finally, we provide some insights into current therapies targeting diabetes and cardiovascular complications and introduce some new agents that may have vasoprotective therapeutic potential in diabetes

The “ABC model”: a non-hydrostatic toy model for use in convective-scale data assimilation investigations

In developing methods for convective-scale data assimilation (DA) it is necessary to consider the full range of motions governed by the compressible Navier-Stokes equations (including non-hydrostatic and ageostrophic flow). These equations describe motion on a wide range of time-scales with non-linear coupling. For the purpose of developing new DA techniques that suit the convective-scale problem it is helpful to use so-called ‘toy models’ that are easy to run, and contain the same types of motion as the full equation set. Such a model needs to permit hydrostatic and geostrophic balance at large-scales, but to allow imbalance at small-scales, and in particular, it needs to exhibit intermittent convection-like behaviour. Existing ‘toy models’ are not always sufficient for investigating these issues. A simplified system of intermediate complexity derived from the Euler equations is presented, which supports dispersive gravity and acoustic modes. In this system the separation of time scales can be greatly reduced by changing the physical parameters. Unlike in existing toy models, this allows the acoustic modes to be treated explicitly, and hence inexpensively. In addition, the non-linear coupling induced by the equation of state is simplified. This means that the gravity and acoustic modes are less coupled than in conventional models. A vertical slice formulation is used which contains only dry dynamics. The model is shown to give physically reasonable results, and convective behaviour is generated by localised compressible effects. This model provides an affordable and flexible framework within which some of the complex issues of convective-scale DA can later be investigated. The model is called the “ABC model” after the three tunable parameters introduced: A (the pure gravity wave frequency), B (the modulation of the divergent term in the continuity equation), and C (defining the compressibility)

LANDSAT TM image data quality analysis for energy-related applications

This project represents a no-cost agreement between National Aeronautic Space Administration Goddard Space Flight Center (NASA GSFC) and the Pacific Northwest Laboratory (PNL). PNL is a Department of Energy (DOE) national laboratory operted by Battelle Memorial Institute at its Pacific Northwest Laboratories in Richland, Washington. The objective of this investigation is to evaluate LANDSAT's thematic mapper (TM) data quality and utility characteristics from an energy research and technological perspective. Of main interest is the extent to which repetitive TM data might support DOE efforts relating to siting, developing, and monitoring energy-related facilities, and to basic geoscientific research. The investigation utilizes existing staff and facility capabilities, and ongoing programmatic activities at PNL and other DOE national laboratories to cooperatively assess the potential usefulness of the improved experimental TM data. The investigation involves: (1) both LANDSAT 4 and 5 TM data, (2) qualitative and quantitative use consideration, and 3) NASA P (corrected) and A (uncorrected) CCT analysis for a variety of sites of DOE interest. Initial results were presented at the LANDSAT Investigator's Workshops and at specialized LANDSAT TM sessions at various conferences

Magnetohydrostatic solar prominences in near-potential coronal magnetic fields

We present numerical magnetohydrostatic solutions describing the gravitationally stratified, bulk equilibrium of cool, dense prominence plasma embedded in a near-potential coronal field. These solutions are calculated using the FINESSE magnetohydrodynamics equilibrium solver and describe the morphologies of magnetic field distributions in and around prominences and the cool prominence plasma that these fields support. The equilibrium condition for this class of problem is usually different in distinct subdomains, separated by free boundaries, across which solutions are matched by suitable continuity or jump conditions describing force balance. We employ our precise finite element elliptic solver to calculate solutions not accessible by previous analytical techniques with temperature or entropy prescribed as free functions of the magnetic flux function, including a range of values of the polytropic index, temperature variations mainly across magnetic field lines and photospheric field profiles sheared close to the polarity inversion line. Out of the many examples computed here, perhaps the most noteworthy is one which reproduces precisely the three-part structure often encountered in observations: a cool dense prominence within a cavity/flux rope embedded in a hot corona. The stability properties of these new equilibria, which may be relevant to solar eruptions, can be determined in the form of a full resistive MHD spectrum using a companion hyperbolic stability solver.Comment: To appear in ApJ August 200

Gauge Group and Topology Change

The purpose of this study is to examine the effect of topology change in the initial universe. In this study, the concept of $G$-cobordism is introduced to argue about the topology change of the manifold on which a transformation group acts. This $G$-manifold has a fiber bundle structure if the group action is free and is related to the spacetime in Kaluza-Klein theory or Einstein-Yang-Mills system. Our results revealed that fundamental processes of compactification in $G$-manifolds. In these processes, the initial high symmetry and multidimensional universe changes to present universe by the mechanism which lowers the dimensions and symmetries.Comment: 8 page

Metformin, lipids and atherosclerosis prevention

Purpose of review: We provide an overview of recent publications that extend clinically relevant knowledge relating to metformin's effects on lipids and atherosclerotic vascular disease and/or provide insights into the drug's mechanisms of action on the heart and vasculature. Recent findings: We focus on original research in humans or in human tissues. Several recently completed randomized clinical trials have reported effects of metformin on surrogate measures of atherosclerotic vascular disease, including carotid–intima media thickness, vascular reactivity and calcification in people with Type 1 (T1D) and Type 2 (T2D) diabetes as well as nondiabetic dysglycaemia. In addition, observational studies have provided novel insights into the mechanisms of metformin's effects on carotid plaque, monocytes/macrophages, vascular smooth muscle and endothelial cells, including via 5’-adenosine monophosphate-activated protein kinase (AMPK) activation. Summary: Recent trials based on surrogate outcome measures have provided further data suggesting protective effects of metformin against vascular disease in youth and adults with Type 1 diabetes, as well as in adults with prediabetes and Type 2 diabetes. In parallel, human tissue and cell studies have provided new insights into pleiotropic effects of metformin and suggest novel drug targets. As metformin is an inexpensive agent with an established safety profile, larger scale clinical trials based on hard clinical outcomes [cardiovascular disease (CVD) events] are now indicated

Peripartum cardiomyopathy: diagnosis and management

No abstract available

Modeling the Sun's open magnetic flux and the heliospheric current sheet

By coupling a solar surface flux transport model with an extrapolation of the heliospheric field, we simulate the evolution of the Sun's open magnetic flux and the heliospheric current sheet (HCS) based on observational data of sunspot groups since 1976. The results are consistent with measurements of the interplanetary magnetic field near Earth and with the tilt angle of the HCS as derived from extrapolation of the observed solar surface field. This opens the possibility for an improved reconstruction of the Sun's open flux and the HCS into the past on the basis of empirical sunspot data.Comment: 16 pages, 5 figures, Accepted for publication in Ap

Altimetry, gravimetry, GPS and viscoelastic modeling data for the joint inversion for glacial isostatic adjustment in Antarctica (ESA STSE Project REGINA)

The poorly known correction for the ongoing deformation of the solid Earth caused by glacial isostatic adjustment (GIA) is a major uncertainty in determining the mass balance of the Antarctic ice sheet from measurements of satellite gravimetry and to a lesser extent satellite altimetry. In the past decade, much progress has been made in consistently modeling ice sheet and solid Earth interactions; however, forward-modeling solutions of GIA in Antarctica remain uncertain due to the sparsity of constraints on the ice sheet evolution, as well as the Earth's rheological properties. An alternative approach towards estimating GIA is the joint inversion of multiple satellite data – namely, satellite gravimetry, satellite altimetry and GPS, which reflect, with different sensitivities, trends in recent glacial changes and GIA. Crucial to the success of this approach is the accuracy of the space-geodetic data sets. Here, we present reprocessed rates of surface-ice elevation change (Envisat/Ice, Cloud,and land Elevation Satellite, ICESat; 2003–2009), gravity field change (Gravity Recovery and Climate Experiment, GRACE; 2003–2009) and bedrock uplift (GPS; 1995–2013). The data analysis is complemented by the forward modeling of viscoelastic response functions to disc load forcing, allowing us to relate GIA-induced surface displacements with gravity changes for different rheological parameters of the solid Earth. The data and modeling results presented here are available in the PANGAEA database (https://doi.org/10.1594/PANGAEA.875745). The data sets are the input streams for the joint inversion estimate of present-day ice-mass change and GIA, focusing on Antarctica. However, the methods, code and data provided in this paper can be used to solve other problems, such as volume balances of the Antarctic ice sheet, or can be applied to other geographical regions in the case of the viscoelastic response functions. This paper presents the first of two contributions summarizing the work carried out within a European Space Agency funded study: Regional glacial isostatic adjustment and CryoSat elevation rate corrections in Antarctica (REGINA)